How high- throughput indentation enables 3D mechanical mapping of fibrotic ECM hydrogel microenvironment
Appnote: Healthy tissues possess a specific stiffness that allows them to function properly. During fibrosis, this stiffness increases significantly. This stiffening occurs due to the excessive deposition of collagen, a major component of scar tissue. Collagen fibers are much stiffer than the healthy components they replace, leading to a loss of elasticity and a more rigid tissue structure.
Our intdentation platforms offer a unique solution to this challenge. These tools can measure the mechanical properties of tissues and cell cultures, including their stiffness (Pa), viscoelasticity or 3D surface topology. Since increased stiffness (Young’s modulus) is a hallmark of fibrosis progression, it can serve as a valuable mechanical biomarker.
Explore automated indentation mapping, bright-field and fluorescence imaging of lung-derived fibrotic ECM hydrogels in 2×96 wellplates.
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